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© Research
Publication : European journal of immunology

The basis for major histocompatibility complex (MHC) and immunoglobulin gene control of helper T cell idiotopes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in European journal of immunology - 01 Apr 1986

Martinez-A C, Pereira P, de la Hera A, Bandeira A, Marquez C, Coutinho A

Link to Pubmed [PMID] – 2938971

Eur. J. Immunol. 1986 Apr;16(4):417-22

BALB/c helper T cells, prepared against 2,4,6-trinitrophenyl (TNP)-derivatized syngeneic spleen cells, fail to recognize other hapten modifications [(4-hydroxy-3-nitrophenyl)acetyl, fluorescein isothiocyanate] of syngeneic cells, as well as TNP-derivatized cells from major histocompatibility complex-congenic donors. T helper cell interactions with “presenting” cells and “target” B lymphocytes are inhibited by monoclonal antibodies directed either to the hapten or to I-A molecules on target cells. Helper activity is also inhibited by monoclonal anti-idiotypic antibodies directed to an idiotope expressed by the TNP-binding myeloma protein MOPC460, but not by soluble TNP-protein conjugates. The study of congenic mouse strains revealed that while the fine specificity of TNP recognition and the quantitative levels of M 460 idiotope expression are I-A linked, the expression of the M 460 idiotope by helper cells is controlled by IgCh-linked genes. Absence of anti-idiotope inhibition of helper cells prepared in anti-mu-suppressed mice suggests, however, that immunoglobulin idiotype expression by T cells results from network interactions selecting available lymphocyte repertoires which operate before antigenic stimulation.

http://www.ncbi.nlm.nih.gov/pubmed/2938971