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© Research
Publication : Biochemical Society Transactions

The anti-allodynic alpha(2)delta ligand pregabalin inhibits the trafficking of the calcium channel alpha(2)delta-1 subunit to presynaptic terminals in vivo.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biochemical Society Transactions - 01 Apr 2010

Claudia S. Bauer; Wahida Rahman; Rafael Lujan; Anthony H. Dickenson; Annette C. Dolphin

Link to Pubmed [PMID] – 20298215

Biochem Soc Trans. 2010 Apr;38(2):525-8

Neuropathic pain is caused by lesion or dysfunction of the peripheral sensory nervous system. Up-regulation of the voltage-gated Ca(2+) channel subunit alpha(2)delta-1 in DRG (dorsal root ganglion) neurons and the spinal cord correlates with the onset of neuropathic pain symptoms such as allodynia in several animal models of neuropathic pain. The clinically important anti-allodynic drugs gabapentin and pregabalin are alpha(2)delta-1 ligands, but how these drugs alleviate neuropathic pain is poorly understood. In the present paper, we review recent advances in our understanding of their molecular mechanisms.

http://www.biochemsoctrans.org/content/38/2/525.long