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  • Director of Center
  • Director of Department
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© Institut Pasteur
Spirochète : bactérie hélicoïdale, flexible et ondulante de longueur variable, non colorable par la coloration de Gram, très mobile (endoflagelles). Trois familles : Spirochaetaceae, Leptospiraceae, et Brachyspiraceae. Principaux genres pathogènes pour l'homme : Borrelia (Borrelia burgdorferi cause de la maladie de Lyme), Treponema (Treponema pallidum cause de la syphillis), Leptospira (Leptospira interrogans serovar icterohaemorrhagiae cause de la maladie de Weil). Image colorisée.
Publication :

Taxonomy and phylogenomics of Leptospira [chapitre 16]

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in - 01 Jan 2024

Cecilia Nieves, Samuel G Huete, Frédéric J Veyrier, Mathieu Picardeau

Link to HAL – pasteur-04616286

Link to DOI – 10.1016/b978-0-323-99886-4.00018-1

Igor Mokrousov; Egor Shitikov. Phylogenomics: Foundations, Methods, and Pathogen Analysis. 1st Edition, Elsevier, pp.359 - 390, 2024, 978-0-323-99886-4 ; 978-0-323-91309-6 (ebook). ⟨10.1016/b978-0-323-99886-4.00018-1⟩

Accurate identification of bacterial species is critical for epidemiologic, phylogenetic, and diagnostic purposes. The classification of leptospires has undergone several changes following the discovery of the leptospirosis agent more than a century ago. With the genomic era, the number of described Leptospira species has more than doubled in recent years. Genotyping, including whole-genome-based typing, allows discrimination of isolates at the subspecies level. Access to genomes has also facilitated the study of gene repertoire and virulence-associated factors. Herein we review the taxonomic classification of the genus Leptospira and highlight recent findings based on the analysis of genomes.