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© Perrine Bomme, Guillaume Duménil, Jean-Marc Panaud.
Coloured scanning electron micrograph (SEM) of Neisseria meningitidis on epithelial cells
Publication : Antimicrobial agents and chemotherapy

Target gene sequencing to define the susceptibility of Neisseria meningitidis to ciprofloxacin.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 28 Jan 2013

Hong E, Thulin Hedberg S, Abad R, Fazio C, Enríquez R, Deghmane AE, Jolley KA, Stefanelli P, Unemo M, Vazquez JA, Veyrier FJ, Taha MK,

Link to Pubmed [PMID] – 23357770

Link to DOI [DOI] – 10.1128/AAC.02184-12

Antimicrob Agents Chemother 2013 Apr; 57(4): 1961-4

Meningococcal gyrA gene sequence data, MICs, and mouse infection were used to define the ciprofloxacin breakpoint for Neisseria meningitidis. Residue T91 or D95 of GyrA was altered in all meningococcal isolates with MICs of ≥ 0.064 μg/ml but not among isolates with MICs of ≤ 0.032 μg/ml. Experimental infection of ciprofloxacin-treated mice showed slower bacterial clearance when GyrA was altered. These data suggest a MIC of ≥ 0.064 μg/ml as the ciprofloxacin breakpoint for meningococci and argue for the molecular detection of ciprofloxacin resistance.

https://pubmed.ncbi.nlm.nih.gov/23357770