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© Shalin E. Abraham, Michael Häusser, Christoph Schmidt-Hieber, University College London
The dentate gyrus is one of the few mammalian brain regions where new neurons are generated throughout life. The image was taken with a confocal microscope from a parasagittal slice of the mouse hippocampus. Cells were labelled with fluorescent markers: Newly generated neurons are red (doublecortin), mature neurons are green (NeuN), and nuclei are blue (DAPI)
Publication : Nature Neuroscience

Synaptic integrative mechanisms for spatial cognition

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature Neuroscience - 26 Oct 2017

Schmidt-Hieber C, Nolan MF

Link to Pubmed [PMID] – 29073648

Nat. Neurosci. 2017 Oct;20(11):1483-1492

Synaptic integrative mechanisms have profound effects on electrical signaling in the brain that, although largely hidden from recording methods that observe the spiking activity of neurons, may be critical for the encoding, storage and retrieval of information. Here we review roles for synaptic integrative mechanisms in the selection, generation and plasticity of place and grid fields, and in related temporal codes for the representation of space. We outline outstanding questions and challenges in the testing of hypothesized models for spatial computation and memory.

https://www.nature.com/articles/nn.4652