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© Research
Publication : Trends in cell biology

Survival of the Fittest: Essential Roles of Cell Competition in Development, Aging, and Cancer

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in cell biology - 16 Jun 2016

Merino MM, Levayer R, Moreno E

Link to Pubmed [PMID] – 27319281

Trends Cell Biol. 2016 Oct;26(10):776-88

Multicellular organisms evolved to resolve conflicts between individual cells, protecting the internal organization of the individual. This is illustrated by cell competition, a process that eliminates suboptimal cells from growing tissues by apoptosis. Since its early characterization in Drosophila an increasing number of conditions have been associated with competition, and mounting evidence demonstrates conservation of this process. We describe here the broad range of contexts that utilize cell competition, including tissue health, aging, and tumor development. We then delineate different models for the processes underlying the recognition and elimination of outcompeted cells.

http://www.ncbi.nlm.nih.gov/pubmed/27319281