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© Research
Publication : Journal of immunology (Baltimore, Md. : 1950)

Superantigen-induced TCR alpha locus secondary rearrangement: role in tolerance induction

Team: Group: ILC development and inflammation
Member: Rachel Golub
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of immunology (Baltimore, Md. : 1950) - 01 Apr 2002

Huang CY, Golub R, Wu GE, Kanagawa O

Link to Pubmed [PMID] – 11907080

J. Immunol. 2002 Apr;168(7):3259-65

Immunization with superantigen in vivo induces transient activation of superantigen-specific T cells, followed by a superantigen-nonresponsive state. In this study, using a TCR alpha knock-in mouse in which the knock-in alpha-chain can be replaced with endogenous alpha-chain through secondary rearrangement, we show that immunization of superantigen changes the TCR alpha-chain expression on peripheral superantigen-specific T cells, induces expression of recombination-activating genes, and generates DNA double-strand breaks at the TCR alpha-chain locus. These results suggest that viral superantigens are capable of inducing peripheral TCR revision. Our findings thus provide a new perspective on pathogen-immune system interaction.