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© Uwe Maskos
Tranche d'hippocampe de souris colorée avec deux toxines spécifiques de sous-types de récepteur nicotinique, en rouge (grains), et en vert (corps cellulaires). L'hippocampe est la zone du cerveau qui gère la mémoire spatiale.
Publication : Organic letters

Substitution effect on the one- and two-photon sensitivity of DMAQ “caging” groups.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Organic letters - 21 Dec 2012

Petit M, Tran C, Roger T, Gallavardin T, Dhimane H, Palma-Cerda F, Blanchard-Desce M, Acher FC, Ogden D, Dalko PI

Link to Pubmed [PMID] – 23214948

Link to DOI – 10.1021/ol3031704

Org Lett 2012 Dec; 14(24): 6366-9

The systematic SAR study of a “caging” group showed a strong influence of the position of the donor dimethylamino group on the efficiency of photolysis of the DMAQ (2-hydroxymethylene-(N,N-dimethylamino)quinoline) caged acetate under one-photon near-UV or two-photon near-IR excitation. Photorelease of l-glutamate by the most efficient 8-DMAQ derivative strongly and efficiently activated glutamate receptors, generating large, fast rising responses similar to those elicited by glutamate photoreleased from the widely used MNI-caged glutamate.