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  • Director of Center
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© Research
Publication : Toxins

Structural Biology and Molecular Modeling to Analyze the Entry of Bacterial Toxins and Virulence Factors into Host Cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Toxins - 24 Jun 2019

Pitard I, Malliavin TE

Link to Pubmed [PMID] – 31238550

Toxins (Basel) 2019 Jun;11(6)

Understanding the functions and mechanisms of biological systems is an outstanding challenge. One way to overcome it is to combine together several approaches such as molecular modeling and experimental structural biology techniques. Indeed, the interplay between structural and dynamical properties of the system is crucial to unravel the function of molecular machinery’s. In this review, we focus on how molecular simulations along with structural information can aid in interpreting biological data. Here, we examine two different cases: (i) the endosomal translocation toxins (diphtheria, tetanus, botulinum toxins) and (ii) the activation of adenylyl cyclase inside the cytoplasm (edema factor, CyA, ExoY).