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© Michaela Muller-Trutwin
HIV
Publication : Nature communications

Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature communications - 05 Jan 2016

Merkenschlager J, Ploquin MJ, Eksmond U, Andargachew R, Thorborn G, Filby A, Pepper M, Evavold B, Kassiotis G

Link to Pubmed [PMID] – 26728651

Nat Commun 2016;7:10281

Antigen receptor diversity underpins adaptive immunity by providing the ground for clonal selection of lymphocytes with the appropriate antigen reactivity. Current models attribute T cell clonal selection during the immune response to T-cell receptor (TCR) affinity for either foreign or self peptides. Here, we report that clonal selection of CD4(+) T cells is also extrinsically regulated by B cells. In response to viral infection, the antigen-specific TCR repertoire is progressively diversified by staggered clonotypic expansion, according to functional avidity, which correlates with self-reactivity. Clonal expansion of lower-avidity T-cell clonotypes depends on availability of MHC II-expressing B cells, in turn influenced by B-cell activation. B cells clonotypically diversify the CD4(+) T-cell response also to vaccination or tumour challenge, revealing a common effect.

http://www.ncbi.nlm.nih.gov/pubmed/26728651