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© Research
Publication : Molecular and cellular endocrinology

Somatostatinergic systems in brain: networks and functions

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Molecular and cellular endocrinology - 22 Sep 2007

Viollet C, Lepousez G, Loudes C, Videau C, Simon A, Epelbaum J

Link to Pubmed [PMID] – 17997029

Mol. Cell. Endocrinol. 2008 May;286(1-2):75-87

Somatostatin is abundantly expressed in mammalian brain. The peptide binds with high affinity to six somatostatin receptors, sst1, sst2A and B, sst3 to 5, all belonging to the G-protein-coupled receptor family. Recent advances in the neuroanatomy of somatostatin neurons and cellular distribution of sst receptors shed light on their functional roles in the neuronal network. Beside their initially described neuroendocrine role, somatostatin systems subserve neuromodulatory roles in the brain, influencing motor activity, sleep, sensory processes and cognitive functions, and are altered in brain diseases like affective disorders, epilepsia and Alzheimer’s disease.

http://www.ncbi.nlm.nih.gov/pubmed/17997029