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© Research
Publication : Development

Somatic stem cell differentiation is regulated by PI3K/Tor signaling in response to local cues.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Development - 15 Sep 2016

Marc Amoyel, Kenzo-Hugo Hillion, Shally R. Margolis, Erika A. Bach

Link to Pubmed [PMID] – 27633989

Development. 2016 Nov 1;143(21):3914-3925

Stem cells reside in niches that provide signals to maintain self-renewal, and differentiation is viewed as a passive process that depends on loss of access to these signals. Here, we demonstrate that the differentiation of somatic cyst stem cells (CySCs) in the Drosophila testis is actively promoted by PI3K/Tor signaling, as CySCs lacking PI3K/Tor activity cannot differentiate properly. We find that an insulin peptide produced by somatic cells immediately outside of the stem cell niche acts locally to promote somatic differentiation through Insulin-like receptor (InR) activation. These results indicate that there is a local ‘differentiation’ niche that upregulates PI3K/Tor signaling in the early daughters of CySCs. Finally, we demonstrate that CySCs secrete the Dilp-binding protein ImpL2, the Drosophila homolog of IGFBP7, into the stem cell niche, which blocks InR activation in CySCs. Thus, we show that somatic cell differentiation is controlled by PI3K/Tor signaling downstream of InR and that the local production of positive and negative InR signals regulates the differentiation niche. These results support a model in which leaving the stem cell niche and initiating differentiation are actively induced by signaling

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http://dev.biologists.org/content/143/21/3914.long