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© Research
Publication : Nature structural & molecular biology

Smc3 acetylation, Pds5 and Scc2 control the translocase activity that establishes cohesin-dependent chromatin loops.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature structural & molecular biology - 01 Jun 2022

Bastié N, Chapard C, Dauban L, Gadal O, Beckouët F, Koszul R,

Link to Pubmed [PMID] – 35710835

Link to DOI – 10.1038/s41594-022-00780-0

Nat Struct Mol Biol 2022 Jun; 29(6): 575-585

Cohesin is a DNA translocase that is instrumental in the folding of the genome into chromatin loops, with functional consequences on DNA-related processes. Chromatin loop length and organization likely depend on cohesin processivity, translocation rate and stability on DNA. Here, we investigate and provide a comprehensive overview of the roles of various cohesin regulators in tuning chromatin loop expansion in budding yeast Saccharomyces cerevisiae. We demonstrate that Scc2, which stimulates cohesin ATPase activity, is also essential for cohesin translocation, driving loop expansion in vivo. Smc3 acetylation during the S phase counteracts this activity through the stabilization of Pds5, which finely tunes the size and stability of loops in G2.

https://pubmed.ncbi.nlm.nih.gov/35710835