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© Research
Publication : FEMS microbiology letters

Shigella spp. and enteroinvasive Escherichia coli pathogenicity factors

Team: Archived: Molecular Microbial Pathogenesis
Member: Claude Parsot
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in FEMS microbiology letters - 15 Sep 2005

Parsot C

Link to Pubmed [PMID] – 16182469

FEMS Microbiol. Lett. 2005 Nov;252(1):11-8

Bacteria of Shigella spp. (S. boydii, S. dysenteriae, S. flexneri and S. sonnei) and enteroinvasive Escherichia coli (EIEC) are responsible for shigellosis in humans, a disease characterized by the destruction of the colonic mucosa that is induced upon bacterial invasion. Shigella spp. and EIEC strains contain a virulence plasmid of approximately 220 kb that encodes determinants for entry into epithelial cells and dissemination from cell to cell. This review presents the current model on mechanisms of invasion of the colonic epithelium by these bacteria and focuses on their pathogenicity factors, particularly the virulence plasmid-encoded type III secretion system.