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© Research
Publication : Science (New York, N.Y.)

Self-organized Notch dynamics generate stereotyped sensory organ patterns in Drosophila

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 06 Apr 2017

Corson F, Couturier L, Rouault H, Mazouni K, Schweisguth F

Link to Pubmed [PMID] – 28386027

Science 2017 Apr;

The emergence of spatial patterns in developing multicellular organisms relies on positional cues and cell-cell communication. Drosophila sensory organs have informed a paradigm where these operate in two distinct steps: prepattern factors drive localized proneural activity, then Notch-mediated lateral inhibition singles out neural precursors. Here we show that self-organization through Notch signaling also organizes the proneural stripes that resolve into rows of sensory bristles on the fly thorax. Patterning, initiated by a gradient of Delta ligand expression, progresses through inhibitory signaling between and within stripes. Thus Notch signaling can support self-organized tissue patterning as a prepattern is transduced by cell-cell interactions into a refined arrangement of cellular fates.

https://www.ncbi.nlm.nih.gov/pubmed/28386027