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© Research
Publication : BMC developmental biology

Selenoprotein N is dynamically expressed during mouse development and detected early in muscle precursors

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in BMC developmental biology - 22 Aug 2009

Castets P, Maugenre S, Gartioux C, Rederstorff M, Krol A, Lescure A, Tajbakhsh S, Allamand V, Guicheney P

Link to Pubmed [PMID] – 19698141

BMC Dev. Biol. 2009;9:46

In humans, mutations in the SEPN1 gene, encoding selenoprotein N (SelN), are involved in early onset recessive neuromuscular disorders, referred to as SEPN1-related-myopathies. The mechanisms behind these pathologies are poorly understood since the function of SelN remains elusive. However, previous results obtained in humans and more recently in zebrafish pointed to a potential role for SelN during embryogenesis. Using qRT-PCR, Western blot and whole mount in situ hybridization, we characterized in detail the spatio-temporal expression pattern of the murine Sepn1 gene during development, focusing particularly on skeletal muscles.

http://www.ncbi.nlm.nih.gov/pubmed/19698141