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© Research
Publication : Journal of immunology (Baltimore, Md. : 1950)

Segregation of Bad from lipid rafts is implicated in the induction of apoptosis

Team: Archived: Nuclear Magnetic Resonance Of Biomolecules
Member: Alphonse Garcia
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of immunology (Baltimore, Md. : 1950) - 01 Apr 2002

Ayllón V, Fleischer A, Cayla X, García A, Rebollo A

Link to Pubmed [PMID] – 11907096

J. Immunol. 2002 Apr;168(7):3387-93

Many molecules relocate subcellularly in cells undergoing apoptosis. Using coimmunoprecipitation experiments we demonstrate that Bad is not associated to 14-3-3 protein, suggesting a new mechanism for the control of the proapoptotic role of Bad. Here we show, by confocal microscopy and cellular fractionation, that Bad is attached to lipid rafts in IL-4-stimulated cells and thymocytes while associated with mitochondria in IL-4-deprived cells. Disruption of lipid rafts by methyl-beta-cyclodextrin treatment induces segregation of Bad from rafts, which correlates with apoptosis. Our results suggest that the interaction of Bad with rafts is a dynamic process regulated by IL-4 and involved in the control of apoptosis.