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© Research
Publication : PloS one

Schistosomiasis coinfection in children influences acquired immune response against Plasmodium falciparum malaria antigens

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 15 Sep 2010

Diallo TO, Remoue F, Gaayeb L, Schacht AM, Charrier N, De Clerck D, Dompnier JP, Pillet S, Garraud O, N'Diaye AA, Riveau G

Link to Pubmed [PMID] – 20856680

PLoS ONE 2010;5(9):e12764

BACKGROUND: Malaria and schistosomiasis coinfection frequently occurs in tropical countries. This study evaluates the influence of Schistosoma haematobium infection on specific antibody responses and cytokine production to recombinant merozoite surface protein-1-19 (MSP1-(19)) and schizont extract of Plasmodium falciparum in malaria-infected children.

METHODOLOGY: Specific IgG1 to MSP1-(19), as well as IgG1 and IgG3 to schizont extract were significantly increased in coinfected children compared to P. falciparum mono-infected children. Stimulation with MSP1-(19) lead to a specific production of both interleukin-10 (IL-10) and interferon-γ (IFN-γ), whereas the stimulation with schizont extract produced an IL-10 response only in the coinfected group.

CONCLUSIONS: Our study suggests that schistosomiasis coinfection favours anti-malarial protective antibody responses, which could be associated with the regulation of IL-10 and IFN-γ production and seems to be antigen-dependent. This study demonstrates the importance of infectious status of the population in the evaluation of acquired immunity against malaria and highlights the consequences of a multiple infection environment during clinical trials of anti-malaria vaccine candidates.

http://www.ncbi.nlm.nih.gov/pubmed/20856680