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© Institut Pasteur
Macrophages et lymphocytes de souris. Image colorisée.
Publication : Stem cells and development

Sca-1+ cardiac progenitor cells and heart-making: a critical synopsis

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Stem cells and development - 14 Jul 2014

Valente M, Nascimento DS, Cumano A, Pinto-do-Ó P

Link to Pubmed [PMID] – 24926741

Stem Cells Dev. 2014 Oct;23(19):2263-73

The identification, in the adult, of cardiomyocyte turnover events and of cardiac progenitor cells (CPCs) has revolutionized the field of cardiovascular medicine. However, the low rate of CPCs differentiation events reported both in vitro and in vivo, even after injury, raised concerns on the biological significance of these subsets. In this Comprehensive Review, we discuss the current understanding of cardiac Lin(-)Sca-1(+) cells in light of what is also known for cellular compartments with similar phenotypes in other organs. The Lin(-)Sca-1(+) heart subset is heterogeneous and displays a mesenchymal profile, characterized by a limited ability to generate cardiomyocytes in vitro and in vivo, even after injury. There is no evidence for Sca-1 expression in embryonic cardiovascular progenitors. In other organs, Sca-1 expression is mainly observed on mesoderm-derived cells, although it is not restricted to stem/progenitor cell populations. It is urgent to determine, at a single cell level, to which extent cardiac Lin(-)Sca-1(+) cells overlap with the fibroblast compartment.

http://www.ncbi.nlm.nih.gov/pubmed/24926741