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© Institut Pasteur/Antoinette Ryter
Salmonella spp. Bactéries à Gram négatif, aérobies ou anaérobies facultatifs à transmission orofécale. Les salmonelles majeures (sérotype typhi et sérotype paratyphi) sont responsables des fièvres typhoïde et paratyphoïde chez l'homme uniquement ; les salmonelles mineures (sérotype typhimurium et sérotype enteritidis) sont impliquées dans 30 à 60 % des gastroentérites et toxiinfections d'origine alimentaire. Image colorisée.
Publication : Emerging infectious diseases

Salmonella enterica Serotype Typhi with nonclassical quinolone resistance phenotype

Team: Enteric Bacterial Pathogens
Member: Francois-Xavier Weill
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Emerging infectious diseases - 01 Jun 2011

Accou-Demartin M, Gaborieau V, Song Y, Roumagnac P, Marchou B, Achtman M, Weill FX

Link to Pubmed [PMID] – 21749778

Emerging Infect. Dis. 2011 Jun;17(6):1091-4

We report Salmonella enterica serotype Typhi strains with a nonclassical quinolone resistance phenotype (i.e., decreased susceptibility to ciprofloxacin but with susceptibility to nalidixic acid) associated with a nonsynonymous mutation at codon 464 of the gyrB gene. These strains, not detected by the nalidixic acid disk screening test, can result in fluoroquinolone treatment failure.