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© Research
Publication : Computational and structural biotechnology journal

Role of lipid transporters in fungal physiology and pathogenicity.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Computational and structural biotechnology journal - 01 Jan 2019

Rizzo J, Stanchev LD, da Silva VKA, Nimrichter L, Pomorski TG, Rodrigues ML,

Link to Pubmed [PMID] – 31921394

Link to DOI [DOI] – 10.1016/j.csbj.2019.09.001

Comput Struct Biotechnol J 2019 ; 17(): 1278-1289

The fungal cell wall and membrane are the most common targets of antifungal agents, but the potential of membrane lipid organization in regulating drug-target interactions has yet to be investigated. Energy-dependent lipid transporters have been recently associated with virulence and drug resistance in many pathogenic fungi. To illustrate this view, we discuss (i) the structural and biological aspects of ATP-driven lipid transporters, comprising P-type ATPases and ATP-binding cassette transporters, (ii) the role of these transporters in fungal physiology and virulence, and (iii) the potential of lipid transporters as targets for the development of novel antifungals. These recent observations indicate that the lipid-trafficking machinery in fungi is a promising target for studies on physiology, pathogenesis and drug development.

https://pubmed.ncbi.nlm.nih.gov/31921394