Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR. | Research - Institut Pasteur

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[Prevalence of community-acquired methicillin-résistant Staphylococcus aureus]

Reinforcing effects of nicotine microinjections into the ventral tegmental area of mice: dependence on cholinergic nicotinic and dopaminergic D1 receptors

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Published in Journal of immunology (Baltimore, Md. : 1950) - 01 Apr 2006

Martín-Cófreces NB, Sancho D, Fernández E, Vicente-Manzanares M, Gordón-Alonso M, Montoya MC, Michel F, Acuto O, Alarcón B, Sánchez-Madrid F,

Link to Pubmed [PMID] – 16547257

J Immunol 2006 Apr; 176(7): 4201-7

The translocation of the microtubule-organizing center (MTOC), its associated signaling complex, and the secretory apparatus is the most characteristic early event that involves the tubulin cytoskeleton of T or NK cells after their interaction with APC or target cells. Our results show that Fyn kinase activity is essential for MTOC reorientation in an Ag-dependent system. Moreover, T cells from Fyn-deficient mice are unable to rearrange their tubulin cytoskeleton in response to anti-CD3-coated beads. Analysis of conjugates of T cells from transgenic OT-I mice with dendritic cells revealed that an antagonist peptide induces translocation of the MTOC, and that this process is impaired in T cells from Fyn(-/-) OT-I mice. In addition, Fyn deficiency significantly affects the MTOC relocation mediated by agonist peptide stimulation. These results reveal Fyn to be a key regulator of tubulin cytoskeleton reorganization in T cells.

Published on: 01 Apr 2006