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© Research
Publication : Virology

Role of class I human leukocyte antigen molecules in early steps of echovirus infection of rhabdomyosarcoma cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Virology - 27 Sep 2008

Chevaliez S, Balanant J, Maillard P, Lone YC, Lemonnier FA, Delpeyroux F

Link to Pubmed [PMID] – 18823925

Virology 2008 Nov;381(2):203-14

Several echoviruses use decay accelerating factor (DAF) as a cell surface receptor. However, most of them require additional cell surface coreceptors. We investigated the respective roles of DAF and class I human leukocyte antigen (HLA) molecules in the early steps of the echovirus 11 (EV11) lifecycle in rhabdomyosarcoma (RD) cells. EV11 infection was inhibited at an early stage by anti-beta2-microglobulin (beta2m) and anti-HLA monoclonal antibodies and by a soluble monochain HLA class I molecule. Expression of class I HLA molecules restored the early steps of the EV11 lifecycle, but its expression was not sufficient for EV11 replication and particle production. Expression of HLA class I molecules was associated with leukocyte cell line permissiveness to EV11 infection. In conclusion, HLA class I molecules are involved in the early steps of EV11 infection of RD cells and appear to participate in a complex interplay of surface molecules acting as coreceptors, including DAF.

http://www.ncbi.nlm.nih.gov/pubmed/18823925