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© Research
Publication : Progress in cell cycle research

Role of chromosomes in assembly of meiotic and mitotic spindles

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Progress in cell cycle research - 01 Jan 1997

Tournebize R, Heald R, Hyman A

Link to Pubmed [PMID] – 9552422

Prog Cell Cycle Res 1997;3:271-84

The assembly of a mitotic spindle requires the interaction of microtubules with chromosomes. As a cell enters mitosis, long microtubules are converted to short ones, as microtubules become unstable. Dynamic microtubules are then stabilised by chromosomes, forming a bipolar spindle. In this review, we discuss the different roles of kinetochores and chromosome arms during spindle assembly. Kinetochores, required for proper chromosomes segregation, capture microtubules and maintain attachment. Chromosome arms greatly enhance microtubule stability, and alone can be sufficient for spindle assembly.

http://www.ncbi.nlm.nih.gov/pubmed/9552422