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© Research
Publication : Seminars in immunology

RIG-I-like receptors: sensing and responding to RNA virus infection

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Seminars in immunology - 17 Jun 2009

Nakhaei P, Genin P, Civas A, Hiscott J

Link to Pubmed [PMID] – 19539500

Semin. Immunol. 2009 Aug;21(4):215-22

Viral and microbial pathogens contain specific motifs or pathogen-associated molecular patterns (PAMPs) that are recognized by cell surface- and endosome-associated Toll-like receptors (TLRs). RNA virus infection is also detected through TLR-independent mechanisms. Early viral replicative intermediates are detected by two recently characterized cystolic viral RNA receptors-RIG-I and MDA-5. Both are DExDH/box RNA helicases, and RIG-I specifically recognizes 5′-triphosphate containing viral RNA and transmits signals that induce type I interferon-mediated host immunity against virus infection. In this review, we will focus on RIG-I-like receptor (RLR) signal transduction and the regulatory mechanisms – ubiquitination, deubiquitination, ISGylation – underlying this important host response.

http://www.ncbi.nlm.nih.gov/pubmed/19539500