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© Perrine Bomme, Guillaume Duménil, Jean-Marc Panaud.
Coloured scanning electron micrograph (SEM) of Neisseria meningitidis on epithelial cells
Publication : Antibiotics (Basel, Switzerland)

Resistance to β-Lactams in Neisseria ssp Due to Chromosomally Encoded Penicillin-Binding Proteins.

Team: Invasive Bacterial Infections
Member: Muhamed-Kheir Taha
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antibiotics (Basel, Switzerland) - 28 Sep 2016

Zapun A, Morlot C, Taha MK,

Link to Pubmed [PMID] – 27690121

Link to DOI – E35

Antibiotics (Basel) 2016 Sep; 5(4):

Neisseria meningitidis and Neisseria gonorrhoeae are human pathogens that cause a variety of life-threatening systemic and local infections, such as meningitis or gonorrhoea. The treatment of such infection is becoming more difficult due to antibiotic resistance. The focus of this review is on the mechanism of reduced susceptibility to penicillin and other β-lactams due to the modification of chromosomally encoded penicillin-binding proteins (PBP), in particular PBP2 encoded by the penA gene. The variety of penA alleles and resulting variant PBP2 enzymes is described and the important amino acid substitutions are presented and discussed in a structural context.