Link to Pubmed [PMID] – 23796922
Link to DOI – 10.1128/AAC.00259-13
Antimicrob Agents Chemother 2013 Sep; 57(9): 4543-4546
There exist numerous genes disseminated by mobile elements that can confer cross-resistance to lincosamides and streptogramin A compounds in staphylococci. This study investigated the nature and means of dissemination of genes responsible for LSA resistance among 24 French clinical isolates screened for reduced susceptibility to lincomycin. The vga(A)v gene was found to be the most prevalent determinant of LSA resistance, while Tn5406 appeared to be its exclusive gene support.