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© Research
Publication : Science (New York, N.Y.)

Requirement for gammadelta T cells in allergic airway inflammation

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 22 May 1998

Zuany-Amorim C, Ruffié C, Hailé S, Vargaftig BB, Pereira P, Pretolani M

Link to Pubmed [PMID] – 9596580

Science 1998 May;280(5367):1265-7

The factors that contribute to allergic asthma are unclear but the resulting condition is considered a consequence of a type-2 T helper (TH2) cell response. In a model of pulmonary allergic inflammation, mice that lacked gammadelta T cells had decreases in specific immunoglobulin E (IgE) and IgG1 and pulmonary interleukin-5 (IL-5) release as well as in eosinophil and T cell infiltration compared with wild-type mice. These responses were restored by administration of IL-4 to gammadelta T cell-deficient mice during the primary immunization. Thus, gammadelta T cells are essential for inducing IL-4-dependent IgE and IgG1 responses and for TH2-mediated airway inflammation to peptidic antigens.

http://www.ncbi.nlm.nih.gov/pubmed/9596580