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Cutting edge: cross-presented intracranial antigen primes CD8+ T cells

Poliovirus induces Bax-dependent cell death mediated by c-Jun NH2-terminal kinase

© Charles Dauguet

Virus VIH-2, second virus du sida isolé en 1985 par l'équipe du Pr. Montagnier de l'Institut Pasteur.

Publication : AIDS (London, England)

Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study)

Team: Viral reservoirs and immune control

Team: Archived: Regulation of Retroviral Infections

Team: HIV, Inflammation and Persistence

Member: Asier Sáez-Cirión

Scientific Fields

Diseases

Organisms

Applications

Technique

Published in AIDS (London, England) - 11 May 2007

Lamine A, Caumont-Sarcos A, Chaix ML, Saez-Cirion A, Rouzioux C, Delfraissy JF, Pancino G, Lambotte O

Link to Pubmed [PMID] – 17457100

AIDS 2007 May;21(8):1043-5

The replicative potential of HIV-1 strains in a well-characterized group of eight HIV controllers was investigated. Replication-competent viruses were detected in CD4 T-cell co-culture supernatants from all HIV controllers. The phylogenetic analysis of C2V4 suggested viral evolution or co-infection or superinfection in two out of the four patients analysed. The vif and vpr genes were normal. Infection with HIV-1 variants with attenuated replicative capacity cannot be a general factor accounting for undetectable viraemia in HIV controllers.

Published on: 11 May 2007