Link to Pubmed [PMID] – 6193750
Ann. Rech. Vet. 1983;14(1):49-55
Ovalbumin was covalently substituted by 6, 18 and 20 residues of Cytidine 5’diphosphocholine per molecule. When injected into BALB/c mice, these products induced distinct immunogenic responses. Without any residue, or with six residues, ovalbumin induced hemagglutinating antibodies (1/256, 21 days after injection) and a response to the passive cutaneous anaphylactic reaction (1/400, 21 days after injection). By contrast, with 18 or 20 residues, ovalbumin brought about the appearance of only a weak titer of hemagglutinating antibodies (1/64, 21 days after injection); no response to the passive cutaneous anaphylactic reaction was observed. No anti-cytidine 5’diphosphocholine antibodies were detected by either reaction. Thus epitope density plays a major role in the IgE immune response to PC-OA.