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© Research
Publication : Biochimie

Regulation of virus-induced interferon-A genes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biochimie - 01 Jul 2002

Civas A, Island ML, Génin P, Morin P, Navarro S

Link to Pubmed [PMID] – 12453636

Biochimie 2002 Jul;84(7):643-54

Different members of the interferon regulatory factor (IRF) family are early activated by viral infection of eukaryotic cells. The IRFs participate in the virus-induced transcriptional regulation of different genes, including the multigenic interferon-A (IFN-A) family, members of which are involved in the establishment of an antiviral state, cell growth inhibition or apoptosis. This study presents the recent progress in the field of virus-induced transactivation and repression of IFN-A gene promoters. Data presented on the modular organization of IFN-A gene promoters and their transactivation dependent on IRF-3 and IRF-7 provide a new insight on the cooperativity mechanisms among the different IRF family members. Data on the transcriptional repression of virus-induced interferon-A promoters by the homeodomain protein Pitx1 contribute to our understanding of the complex differential transcriptional activation, repression and antirepression of the IFN-A genes.

http://www.ncbi.nlm.nih.gov/pubmed/12453636