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  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
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© Research
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Published in Médecine sciences : M/S - 01 Oct 2007

Lobry C, Weil R

Link to Pubmed [PMID] – 17937895

Med Sci (Paris) 2007 Oct;23(10):857-61

The transcription factor NF-kappaB has a central role in coordinating the expression of a wide variety of genes that control the immune system. Defining the proteins and the mechanisms that transmit signals from the T-cell receptor to NF-kappaB is therefore an important goal for immunologists. Although most players have probably been identified, relatively little is known about the detailed molecular mechanisms involved in the cascade leading to NF-kappaB activation following engagement of the T cell receptor by a foreign antigen. PKCtheta, CARMA1, BCL-10, MALT1 and caspase 8 are signalling proteins that have a key role in antigen receptor-mediated lymphocyte activation through the NF-kappaB pathway. In this review, we discuss recent insights into this specific signal transduction cascade, and the way it is regulated. Several lines of evidence, mainly from biochemical studies of T cells clearly indicate that phosphorylation, ubiquitination and degradation are key control elements in the positive and negative regulation of the NF-kappaB pathway in response to TCR stimulation.