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© Charles Dauguet
Virus VIH-1 (HIV-1), agent du sida, à la surface d'un lymphocyte. Image colorisée.
Publication : Clinical immunology (Orlando, Fla.)

Reduction of death receptor 5 expression and apoptosis of CD4+ T cells from HIV controllers

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Clinical immunology (Orlando, Fla.) - 07 Aug 2014

Barblu L, Smith N, Durand S, Scott-Algara D, Boufassa F, Delfraissy JF, Cimarelli A, Lambotte O, Herbeuval JP

Link to Pubmed [PMID] – 25110157

Clin. Immunol. 2014 Nov;155(1):17-26

TNF-related apoptosis ligand (TRAIL) induces apoptosis of HIV-1-exposed CD4 T cells expressing the death receptor 5 (DR5) in vitro and has been associated with reduced CD4 T cell number in viremic HIV-1-infected patients. Alterations of the TRAIL/DR5 apoptotic pathway could be involved in the absence of massive CD4 T cell depletion in HIV-1-infected controllers (HIC). We studied here apoptosis of CD4 T cells from HIV-infected progressors and controllers. Reduced apoptosis of CD4 T cells from HIC was observed upon HIV stimulation. This lower apoptosis correlated with a deficiency of DR5 cell surface expression by CD4 T cells upon HIV-1 stimulation. The significant lower apoptosis observed in CD4 T cells after HIV exposure, associated with lower expression of membrane DR5 could explain the better survival of HIV-specific CD4 T cells from HIV controllers. The levels of DR5 cell surface expression on CD4 T cells could represent a new prognostic marker.

https://www.ncbi.nlm.nih.gov/pubmed/25110157