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© Artur Scherf
Scanning Electron Microscopy of Red Blood Cell infected by Plasmodium falciparum.
Publication : Antimicrobial agents and chemotherapy

Reduced polymorphism in the Kelch propeller domain in Plasmodium vivax isolates from Cambodia

Team: Biology of Host-parasite Interactions
Member: Didier Ménard
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 10 Nov 2014

Popovici J, Kao S, Eal L, Bin S, Kim S, Ménard D

Link to Pubmed [PMID] – 25385109

Antimicrob. Agents Chemother. 2015 Jan;59(1):730-3

Polymorphism in the ortholog gene of the Plasmodium falciparum K13 gene was investigated in Plasmodium vivax isolates collected in Cambodia. All of them were Sal-1 wild-type alleles except two (2/284, 0.7%), and P. vivax K12 polymorphism was reduced compared to that of the P. falciparum K13 gene. Both mutant allele isolates had the same nonsynonymous mutation at codon 552 (V552I) and were from Ratanak Kiri province. These preliminary data should encourage additional studies for associating artemisinin or chloroquine resistance and K12 polymorphism.