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© A. Alanio, E. Perret
Prolifération de Cryptococcus neoformans dans des macrophages murins.
Publication : F1000Research

Recent advances in managing HIV-associated cryptococcal meningitis

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in F1000Research - 28 May 2019

Boyer-Chammard T, Temfack E, Alanio A, Jarvis JN, Harrison TS, Lortholary O

Link to Pubmed [PMID] – 31275560

F1000Res 2019;8

The recent development of highly sensitive and specific point-of-care tests has made it possible to diagnose HIV-associated cryptococcal meningitis within minutes. However, diagnostic advances have not been matched by new antifungal drugs and treatment still relies on old off-patent drugs: amphotericin B, flucytosine and fluconazole. Cryptococcal meningitis treatment is divided in three phases: induction, consolidation and maintenance. The induction phase, aimed at drastically reducing cerebrospinal fluid fungal burden, is key for patient survival. The major challenge in cryptococcal meningitis management has been the optimisation of induction phase treatment using the limited number of available medications, and major progress has recently been made. In this review, we summarise data from key trials which form the basis of current treatment recommendations for HIV-associated cryptococcal meningitis.

https://www.ncbi.nlm.nih.gov/pubmed/31275560