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© Research
Publication : Small GTPases

Rac-ing to the plasma membrane: the long and complex work commute of Rac1 during cell signaling

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Small GTPases - 01 Jan 2012

Bustelo XR, Ojeda V, Barreira M, Sauzeau V, Castro-Castro A

Link to Pubmed [PMID] – 22714419

Small GTPases 2012 Jan-Mar;3(1):60-6

The functional cycle of the Rac1 GTPase involves a large number of steps, including post-translational processing, cytosolic sequestration by RhoGDIs, translocation to specific subcellular localizations, activation by GDP/GTP exchange, inactivation by GTP hydrolysis, and re-formation of cytosolic Rac1/RhoGDI inhibitory complexes. Here, we summarize the current knowledge about the regulation of those steps. In addition, we discuss a recently described, cytoskeletal-dependent feed-back loop that favors the efficient translocation and activation of Rac subfamily proteins during cell signaling. This route is mediated by a heteromolecular protein complex composed of the cytoskeletal protein coronin1A, the Dbl family member ArhGEF7, the serine/threonine kinase Pak1, and the Rac1/RhoGDI dimer. This route promotes the translocation of Rac1/RhoGDI to F-actin-rich juxtamembrane areas, the Pak1-dependent release of Rac1 from the Rac1/RhoGDI complex, and Rac1 activation. This pathway is important for optimal Rac1 activation during the signaling of the EGF receptor, integrins, and the antigenic T-cell receptor.

http://www.ncbi.nlm.nih.gov/pubmed/22714419