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© Institut Pasteur/Antoinette Ryter
Coupe de Mycobacterium bovis ou bacille de Calmette et Guérin (BCG). Souche atténuée de bacille vivant, à l'origine du vaccin antituberculeux délivré par voie intradermique ou scarifications (Grossissement X 70000). Image colorisée.
Publication : Infection and immunity

Priming by DNA immunization augments protective efficacy of Mycobacterium bovis Bacille Calmette-Guerin against tuberculosis

Team: Immunobiology and Therapy
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Infection and immunity - 01 Jun 2001

Feng CG, Palendira U, Demangel C, Spratt JM, Malin AS, Britton WJ

Link to Pubmed [PMID] – 11349095

Infect. Immun. 2001 Jun;69(6):4174-6

Sequential immunization with mycobacterial antigen Ag85B-expressing DNA and Mycobacterium bovis bacille Calmette-Guerin (BCG) was more effective than BCG immunization in protecting against Mycobacterium tuberculosis infection. Depletion of the CD8(+) T cells in the immunized mice impaired protection in their spleens, indicating that this improved efficacy was partially mediated by CD8(+) T cells.