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© Research
Publication : Frontiers in cell and developmental biology

Primary Mammary Organoid Model of Lactation and Involution.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Frontiers in cell and developmental biology - 01 Jan 2020

Sumbal J, Chiche A, Charifou E, Koledova Z, Li H,

Link to Pubmed [PMID] – 32266252

Link to DOI – 10.3389/fcell.2020.00068

Front Cell Dev Biol 2020 ; 8(): 68

Mammary gland development occurs mainly after birth and is composed of three successive stages: puberty, pregnancy and lactation, and involution. These developmental stages are associated with major tissue remodeling, including extensive changes in mammary epithelium, as well as surrounding stroma. Three-dimensional (3D) mammary organoid culture has become an important tool in mammary gland biology and enabled invaluable discoveries on pubertal mammary branching morphogenesis and breast cancer. However, a suitable 3D organoid model recapitulating key aspects of lactation and involution has been missing. Here, we describe a robust and straightforward mouse mammary organoid system modeling lactation and involution-like process, which can be applied to study mechanisms of physiological mammary gland lactation and involution as well as pregnancy-associated breast cancer.

https://pubmed.ncbi.nlm.nih.gov/32266252