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© Research
Publication : FEMS immunology and medical microbiology

Prevalence of anti-R-13 antibodies in human Trypanosoma cruzi infection

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in FEMS immunology and medical microbiology - 01 Dec 1995

Aznar C, Lopez-Bergami P, Brandariz S, Mariette C, Liegeard P, Alves MD, Barreiro EL, Carrasco R, Lafon S, Kaplan D

Link to Pubmed [PMID] – 8745008

FEMS Immunol. Med. Microbiol. 1995 Dec;12(3-4):231-8

Infection with Trypanosoma cruzi develops in three phases: acute, indeterminate or asymptomatic, and chronic phase (with cardiac or digestive manifestations). Moreover, transmission may occur from infected mothers to newborn, the so-called congenital form. In the present study, humoral responses against T. cruzi total extract and against the 13 amino acid peptide named R-13 derived from the parasite ribosomal P protein, previously described as a possible marker of chronic Chagas heart disease, were determined in chagasic patients and in blood bank donors from endemic areas. While in sera from acute phase, only IgM anti-T.cruzi response was observed, both IgM and IgG anti-T. cruzi antibodies were detected in sera from congenitally infected newborns. The percentage of positive response in sera from blood bank donors was relatively high in endemic regions. Antibodies against the R-13 peptide were present in a large proportion of cardiac chagasic patients but were totally lacking in patients with digestive form of Chagas’ disease. Furthermore, anti-R-13 positive responses were detected in congenitally infected newborns.

https://www.ncbi.nlm.nih.gov/pubmed/8745008