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© Charles Dauguet
Virus VIH-1 (HIV-1), agent du sida, à la surface d'un lymphocyte. Image colorisée.
Publication : American journal of reproductive immunology (New York, N.Y. : 1989)

Predominant intracellular expression of CXCR4 and CCR5 in purified primary trophoblast cells from first trimester and term human placentae

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in American journal of reproductive immunology (New York, N.Y. : 1989) - 01 Oct 2003

Maldonado-Estrada J, Menu E, Roques P, Vaslin B, Dautry-Varsat A, Barré-Sinoussi F, Chaouat G

Link to Pubmed [PMID] – 14672331

Am. J. Reprod. Immunol. 2003 Oct;50(4):291-301

PROBLEM: The aim of the present study was to define the expression of CXCR4 and CCR5 on non-cultured non-stimulated primary human trophoblast cells (TCs) immediately after their immunopurification.

METHOD OF STUDY: We have evaluated by flow cytometric analysis and immunofluorescence, highly purified primary TCs prepared from first trimester (8.2 +/- 0.3 weeks, n = 15) and term (Caesarean section, n = 10) placentae for the cell surface and intracellular expression of CXCR4 and CCR5.

RESULTS: There was a high level of individual variability for CXCR4 and CCR5 expression between trophoblast batches. In first trimester and term placentae TCs, we found a greater number of TCs preparations expressing intracellular CXCR4 than CCR5 (P < 0.05). Both receptors were predominantly localized in the intracellular compartment of TCs, whatever if isolated from first trimester or term placentae.

CONCLUSIONS: The functional consequences of the predominance of CXCR4 expression and of cellular addressing are briefly discussed.

http://www.ncbi.nlm.nih.gov/pubmed/14672331