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© Research
Publication : mSphere

Potential of chemically synthesized oligosaccharides to define the carbohydrate moieties of the fungal cell wall responsible for the human immune response, using Aspergillus fumigatus galactomannan as a model

Member: Sarah Wong
Member: Thierry Fontaine
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in mSphere - 08 Jan 2020

Wong SSW, Krylov VB, Argunov DA, Karelin AA, Bouchara JP, Fontaine T, Latgé JP, Nifantiev NE

Link to Pubmed [PMID] – 31915215

Link to DOI – e00688-1910.1128/mSphere.00688-19

mSphere 2020 01; 5(1):

Methodologies to identify epitopes or ligands of the fungal cell wall polysaccharides influencing the immune response of human pathogens have to date been imperfect. Using the galactomannan (GM) of Aspergillus fumigatus as a model, we have shown that synthetic oligosaccharides of distinct structures representing key fragments of cell wall polysaccharides are the most precise tools to study the serological and immunomodulatory properties of a fungal polysaccharide.