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© Research
Publication : Journal of affective disorders

Polymorphism of Toll-like receptor 4 gene in bipolar disorder

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of affective disorders - 17 Oct 2013

Oliveira J, Busson M, Etain B, Jamain S, Hamdani N, Boukouaci W, Amokrane K, Bennabi M, Le Guen E, Dargél AA, Houenou J, Ivanova R, Bellivier F, Henry C, Kahn JP, Charron D, Krishnamoorthy R, Vervoitte L, Leboyer M, Tamouza R

Link to Pubmed [PMID] – 24176535

J Affect Disord 2014 Jan;152-154:395-402

Bipolar disorder (BD) is considered as a multifactorial disorder involving complex interactions between genetic and environmental factors, where immune dysfunction is thought to play a key etiopathogenic role. In particular, excess of winter births associated with early-life infections raise the possibility of the implication of innate immunity. Given the pivotal role of Toll-like receptor 4 (TLR-4), a major innate immune sensor molecule, we hypothesized that genetic variations of TLR-4 may be associated to BD.