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© Research
Publication : Bioorganic & medicinal chemistry letters

Polymerase incorporation of pyrene-nucleoside triphosphates

Team: Bioorganic chemistry of nucleic acids
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Bioorganic & medicinal chemistry letters - 05 May 2012

Hollenstein M, Wojciechowski F, Leumann CJ

Link to Pubmed [PMID] – 22633686

Bioorg. Med. Chem. Lett. 2012 Jul;22(13):4428-30

Pyrene-deoxynucleoside triphosphates (dPTPs), varying by the positioning of the aromatic system, were synthesized. Their ability to function as substrates for the Klenow fragment of Escherichia coli DNA polymerase I and the TdT polymerase was assessed. The dPTPs are all equally well tolerated by the Klenow fragment, and lead to elongation of up to 5 extra nucleotides of a ssDNA primer in a TdT-mediated reaction. The tailing efficiency of the dPTPs compares favorably to other less drastically modified dNTPs.