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© Research
Publication : The Journal of general virology

Poliovirus transcytosis through M-like cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of general virology - 01 Sep 2002

Ouzilou L, Caliot E, Pelletier I, Prévost MC, Pringault E, Colbère-Garapin F

Link to Pubmed [PMID] – 12185271

J. Gen. Virol. 2002 Sep;83(Pt 9):2177-82

During the digestive-tract phase of infection, poliovirus (PV) is found in the oropharynx and the intestine. It has been proposed that PV enters the organism by crossing M cells, which are scattered in the epithelial sheet covering lymphoid follicles of Peyer’s patches. However, PV translocation through M cells has never been demonstrated. A model of M-like cells has been previously developed using monolayers of polarized Caco-2 enterocytes cocultured with lymphocytes isolated from Peyer’s patches. In this model, lymphoepithelial interactions trigger the appearance of epithelial cells having morphological and functional characteristics of M cells. We have demonstrated efficient, temperature-dependent PV transcytosis in Caco-2 cell monolayers containing M-like cells. This experimental evidence is consistent with M cells serving as gateways allowing PV access to the basal face of enterocytes, the underlying immune follicle cells, and PV transport toward mesenteric lymph nodes.

http://www.ncbi.nlm.nih.gov/pubmed/12185271