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© Marie Prévost, Institut Pasteur
Image of a portion of a Xenopus oocyte expressing a channel receptor.
Publication : Current opinion in pharmacology

Photo-isomerizable tweezers to probe ionotropic receptor mechanisms.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in pharmacology - 26 Dec 2021

Peverini L, Dunning K, Peralta FA, Grutter T,

Link to Pubmed [PMID] – 34965483

Link to DOI – S1471-4892(21)00176-410.1016/j.coph.2021.11.011

Curr Opin Pharmacol 2021 Dec; 62(): 109-116

Ligand-gated ion channels (LGIC, also referred to as ionotropic receptors) are important transmembrane proteins that open to allow ions to flow across the membrane and locally modify the membrane potential in response to the binding of a ligand. For more than a decade, a tremendous effort has been carried out in the determination of many LGIC structures in high resolution, leading to an unprecedented molecular description of channel gating. However, it is sometimes difficult to classify experimentally derived structures to their corresponding functional states, and alternative methods may help resolve or refine this issue. In this review, we focus on the application of photo-isomerizable tweezers (PIT) as a powerful strategy to interrogate molecular mechanisms of LGIC while assessing their functionality by electrophysiology.

https://pubmed.ncbi.nlm.nih.gov/34965483