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  • program_project
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  • whocc
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  • tool
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  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinician Researcher
  • Department Manager
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
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© Research
Publication : Advances in experimental medicine and biology

Pertussis in Low and Medium Income Countries: A Pragmatic Approach.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Advances in experimental medicine and biology - 01 Jan 2019

Guiso N, Taieb F

Link to Pubmed [PMID] – 31342458

Link to DOI – 10.1007/5584_2019_409

Adv Exp Med Biol 2019 ; 1183(): 137-149

Pertussis is a vaccine preventable disease since late 1940s. However, it is still endemic in all countries and occurs in epidemic cycles. The number of cases/deaths has decreased during the last decade but a high number of deaths persists in Low and Medium Income Countries (LMIC). The epidemiological situation in LMIC is not precisely known due to lack of surveillance and specific diagnostic tools. A pragmatic approach in these countries should be to establish; (i) a hospital-based surveillance in the largest cities of the country with clinicians and nurses trained to detect clinical symptoms, to obtain biological samples for specific analysis and diagnosis; (ii) a reference laboratory as part of an international network of reference laboratories, under quality assurance, and able to perform at least PCR diagnosis and if possible detection of antibiotic resistance. This surveillance network would allow specific diagnosis of pertussis and facilitate the reporting of cases at national level, thereby improving awareness of the disease at clinician, population and decision maker levels. This network could allow a better evaluation of vaccine coverage, timely vaccination and impacts of modification of national vaccine strategy or type of pertussis vaccine used. Collaboration between this network and basic scientists should be strengthened through translational research projects in order to improve fundamental knowledge on pertussis in LMIC and help clinicians’ access to specific diagnostic tools.