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© Valérie Zeitoun
Stéthoscope. Centre Médical de l'Institut Pasteur (CMIP).
Publication : American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Persistence of yellow fever vaccine-induced antibodies after solid organ transplantation

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 08 Jul 2013

Wyplosz B, Burdet C, François H, Durrbach A, Duclos-Vallée JC, Mamzer-Bruneel MF, Poujol P, Launay O, Samuel D, Vittecoq D, Consigny PH,

Link to Pubmed [PMID] – 23834702

Am. J. Transplant. 2013 Sep;13(9):2458-61

Immunization using live attenuated vaccines represents a contra-indication after solid organ transplantation (SOT): consequently, transplant candidates planning to travel in countries where yellow fever is endemic should be vaccinated prior to transplantation. The persistence of yellow fever vaccine-induced antibodies after transplantation has not been studied yet. We measured yellow-fever neutralizing antibodies in 53 SOT recipients vaccinated prior to transplantation (including 29 kidney recipients and 18 liver recipients). All but one (98%) had protective titers of antibodies after a median duration of 3 years (min.: 0.8, max.: 21) after transplantation. The median antibody level was 40 U/L (interquartile range: 40-80). For the 46 patients with a known or estimated date of vaccination, yellow-fever antibodies were still detectable after a median time of 13 years (range: 2-32 years) post-immunization. Our data suggest there is long-term persistence of antibodies to yellow fever in SOT recipients who have been vaccinated prior to transplantation.

https://www.ncbi.nlm.nih.gov/pubmed/23834702