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© Research
Publication : Cellular and molecular life sciences : CMLS

Peripheral B cell survival

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cellular and molecular life sciences : CMLS - 01 Aug 2000

Agenès F, Rosado MM, Freitas AA

Link to Pubmed [PMID] – 11028914

Cell. Mol. Life Sci. 2000 Aug;57(8-9):1220-8

Recent findings suggest that lymphocyte survival is a continuous active process and support the role of B cell receptor engagement in B cell survival. In this context the conflict of survival interests between the diverse B cells gives rise to a pattern of interactions which mimics the behavior of complex ecological systems. In response to competition lymphocytes modify their survival requirements and diverge to occupy different immunological niches through differentiation. Thus naive and memory-activated B cell populations show independent homeostatic regulation. We discuss how niche differentiation allows the coexistence of different cell types and guarantees both repertoire diversity and efficient immune responses.

http://www.ncbi.nlm.nih.gov/pubmed/11028914