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© Research
Publication : Pathogens (Basel, Switzerland)

Pathogenic Delivery: The Biological Roles of Cryptococcal Extracellular Vesicles.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Pathogens (Basel, Switzerland) - 16 Sep 2020

de Oliveira HC, Castelli RF, Reis FCG, Rizzo J, Rodrigues ML,

Link to Pubmed [PMID] – 32948010

Link to DOI – E75410.3390/pathogens9090754

Pathogens 2020 Sep; 9(9):

Extracellular vesicles (EVs) are produced by all domains of life. In fungi, these structures were first described in Cryptococcus neoformans and, since then, they were characterized in several pathogenic and non-pathogenic fungal species. Cryptococcal EVs participate in the export of virulence factors that directly impact the Cryptococcus-host interaction. Our knowledge of the biogenesis and pathogenic roles of Cryptococcus EVs is still limited, but recent methodological and scientific advances have improved our understanding of how cryptococcal EVs participate in both physiological and pathogenic events. In this review, we will discuss the importance of cryptococcal EVs, including early historical studies suggesting their existence in Cryptococcus, their putative mechanisms of biogenesis, methods of isolation, and possible roles in the interaction with host cells.

https://pubmed.ncbi.nlm.nih.gov/32948010