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© Research
Publication : Molecular biology and evolution

Parallel evolution of adaptive mutations in Plasmodium falciparum mitochondrial DNA during atovaquone-proguanil treatment.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Molecular biology and evolution - 01 Aug 2007

Musset L, Le Bras J, Clain J,

Link to Pubmed [PMID] – 17488741

Link to DOI – 10.1093/molbev/msm087

Link to HAL - Pasteur – https://hal-riip.archives-ouvertes.fr/pasteur-00577268

Mol Biol Evol 2007 Aug; 24(8): 1582-5

Here we provide direct evidence that two adaptive nucleotide changes in the same codon (268) of the cytochrome b gene (pfcytb) each occurred repeatedly in independent Plasmodium falciparum lineages exposed to the antimalarial drug atovaquone-proguanil (AP). We analyzed the history of 7 AP resistance alleles from clinical isolates by sequencing the mitochondrial (mt) genome that encodes the pfcytb gene and found that a distinct mt haplotype was associated with each AP resistance allele. By comparing mt sequences and microsatellite genotypes of the isolates both before treatment initiation and at the day of failure for each uncured patient, we observed that the AP resistance alleles occurred and spread within the patients. These data demonstrate that identical AP resistance alleles have multiple independent origins and provide an example of parallel evolution driven by drug treatment selection in P. falciparum.

https://pubmed.ncbi.nlm.nih.gov/17488741